Erica mazaika ware3/4/2023 ![]() Genotype, along with cumulative chemotherapy dosage and traditional cardiovascular risk factors, improves the identification of patients who have cancer at highest risk for CCM. Ware, Ph.D., M.R.C.P., Jian Li, Ph.D., Erica Mazaika, M.A. CONCLUSIONS: Unrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtvs, increased the risk for CCM in children and adults, and adverse cardiac events in adults. Cardiologist James Ware, Clinical Senior Lecturer in Genomic Medicine at the. Consistent with human data, anthracycline-treated TTNtv mice and isolated TTNtv cardiomyocytes showed sustained contractile dysfunction unlike wild-type ( P=0.0004 and P<0.002, respectively). Sanjay K Prasad, Stuart A Cook, James S Ware, Roddy Walsh. Adult patients who had CCM with TTNtvs experienced more heart failure and atrial fibrillation ( P=0.003) and impaired myocardial recovery ( P=0.03) than those without. Myocarditis and long-term survival in peripartum cardiomyopathy, 10.1067/mhj.2000.110091 Ware James S., Li Jian, Mazaika Erica, Yasso Christopher M. Nicola Whiffin, Risha Govind, Erica Mazaika, Antonio de Marvao, Timothy J W Dawes. Titin-truncating variants (TTNtvs) predominated, occurring in 7.5% of patients with CCM versus 1.1% of The Cancer Genome Atlas participants ( P=7.36e-08), 0.7% of healthy volunteers ( P=3.42e-06), and 0.6% of the reference population ( P=5.87e-14). Mathes 9 Manchester High School 11:18.55 - Asher Mazaika 10 Grafton High. Among 9 prioritized genes, patients with CCM had more rare protein-altering variants than comparative cohorts ( P≤1.98e-04). Agnes 26.14 - Daquan Curry 9 Jamestown 26.74 - Eric Cyr 11 Deep Run. ![]() Adult patients with CCM had cardiovascular risk factors similar to the US population. James S Ware 1, Jian Li, Erica Mazaika, Christopher M Yasso, Tiffany DeSouza, Thomas P Cappola, Emily J Tsai, Denise Hilfiker-Kleiner, Chizuko A Kamiya, Francesco Mazzarotto, Stuart A Cook, Indrani Halder, Sanjay K Prasad, Jessica Pisarcik, Karen Hanley-Yanez, Rami Alharethi, Julie Damp, Eileen Hsich, Uri Elkayam, Richard Sheppard, Angela. RESULTS: CCM was diagnosed 0.4 to 9 years after chemotherapy 90% of these patients received anthracyclines. A prevalent CCM genotype was modeled in anthracycline-treated mice. Clinical characteristics and outcomes were assessed and stratified by genotypes. The prevalence of rare variants was compared between CCM cohorts and The Cancer Genome Atlas participants (n=2053), healthy volunteers (n=445), and an ancestry-matched reference population. Cardiomyopathy genes, including 9 prespecified genes, were sequenced. Erica Mazaika's 19 research works with 1,104 citations and 3,991 reads, including: Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited. METHODS: We studied 213 patients with CCM from 3 cohorts: retrospectively recruited adults with diverse cancers (n=99), prospectively phenotyped adults with breast cancer (n=73), and prospectively phenotyped children with acute myeloid leukemia (n=41). We hypothesized that rare variants in cardiomyopathy genes contribute to CCM. Mostrando 1 - 19 Resultados de 19 Para Buscar ''Mazaika, Erica'', tiempo de consulta: 1. These parameters incompletely account for substantial interindividual susceptibility to CCM. BACKGROUND: Cancer therapy-induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |